Think the only hindrance for OPQS in GC is the lack of climbing depth may lead to time losses in the higher mountain stages if they get distanced (even slightly) by a surge. Be interesting to see how they go though.
Having said that I think they are the only team that can expect to compete in any type of race/stage from one dayers to high mountains and (T)TTs, its whether they can do it consecutively that will be the key.